CPT® Code 89291

Biopsy, oocyte polar body or embryo blastomere, microtechnique (for pre-implantation genetic diagnosis); greater than 5 embryos

The procedure described by CPT® Code 89291 involves the biopsy of oocyte polar bodies or embryo blastomeres using microtechniques specifically for pre-implantation genetic diagnosis (PGD). This procedure is particularly relevant for patients who are known carriers of specific genetic diseases, as it allows for the identification of genetically normal oocytes or embryos prior to implantation. The process begins with a microscopic examination of the oocyte to assess its maturity if the biopsy is performed on an oocyte. In the case of an embryo, the viability of the embryo is also evaluated. During the procedure, the oocyte or embryo is carefully held in place with a holding pipette while being observed under a microscope. A small incision is made in the oocyte or embryo using either mechanical or enzymatic methods. Following this, a biopsy pipette is utilized to extract one or two polar bodies or blastomeres, which are then sent for genetic analysis. It is important to note that this code is applicable when the biopsy is performed on more than five oocytes or embryos, distinguishing it from CPT® Code 89290, which is used for the biopsy of five or fewer oocytes or embryos.