CPT® Code 90375

The rabies immune globulin (RIg) is a specialized immunizing agent that provides immediate, short-term passive immunity against the rabies virus. This preparation consists of a concentrated solution of antibodies derived from pooled human donor blood, specifically from individuals who have developed immunity to rabies. Unlike active immunization, where the recipient's immune system is stimulated to produce its own antibodies, the administration of RIg offers immediate protection by supplying pre-formed antibodies directly into the bloodstream. This passive immunity is crucial for individuals who have been exposed to the rabies virus, as it helps to neutralize the virus and prevent the onset of the disease. The code CPT® 90375 specifically pertains to the reporting of human rabies immune globulin for either intramuscular or subcutaneous administration. It is important to note that this code solely represents the immune globulin product used and does not encompass any additional treatments or vaccines that may be required in conjunction with rabies exposure. For cases where a heat-treated version of the immune globulin is utilized, the code 90376 should be reported, indicating that the product has undergone a specific heat treatment process designed to inactivate viruses and minimize the risk of blood-borne viral transmission.