CPT® Code 90376

The CPT® Code 90376 refers to rabies immune globulin, specifically the heat-treated variant (RIg-HT), which is intended for intramuscular and/or subcutaneous administration. This immunizing agent is a concentrated solution containing antibodies that provide effective, short-term passive immunity against rabies. Unlike active immunization, where the recipient's immune system is stimulated to produce its own antibodies, the use of rabies immune globulin offers immediate protection through the direct introduction of pre-formed antibodies into the body. This passive immunity is crucial for individuals who have been exposed to the rabies virus, as it helps to neutralize the virus and prevent the onset of the disease. The immune globulin is derived from pooled donor blood from individuals who have already developed antibodies against rabies, ensuring a robust source of protection. The specific code 90376 is designated for the use of human rabies immune globulin that has undergone a heat treatment process at temperatures of 58-60 degrees Celsius for a duration of 10 hours. This process is essential for inactivating potential viruses and minimizing the risk of blood-borne viral transmission, thereby enhancing the safety of the product for recipients.