CPT® Code 90627

The CPT® Code 90627 refers to the tick-borne encephalitis virus vaccine, which is an inactivated vaccine specifically designed for intramuscular administration. This vaccine is crucial for providing protection against tick-borne encephalitis (TBE), a viral infection that can have severe consequences, including neurological complications such as muscle weakness, cognitive decline, and in some cases, permanent paralysis or death. Unlike immune globulins that offer temporary, passive immunity, this vaccine works by stimulating the recipient's immune system to develop active, long-lasting immunity. It does this by introducing altered forms of the TBE virus, prompting the immune system to produce antibodies that can effectively combat the virus upon future exposure. The TICOVAC™ vaccine, which received approval in the U.S. in 2021, is effective for both children and adults who are traveling to or living in areas where TBE is prevalent. While the virus is not endemic in the United States, it poses a significant risk in various regions of Europe and Asia. For accurate reporting, it is important to note that code 90627 is designated for the 0.5 mL dosage of the vaccine, while a separate code, 90626, is used for the 0.25 mL dosage. Additionally, the administration of the vaccine via intramuscular injection should be reported separately, with the injection typically occurring in the arm for adults and in the thigh for children.