© Copyright 2026 American Medical Association. All rights reserved.
The rapid desensitization procedure, as denoted by CPT® Code 95180, is a critical medical intervention designed for patients who have previously experienced hypersensitivity reactions to essential or life-saving medications, such as insulin, penicillin, or equine serum. This procedure is particularly important in situations where the administration of these drugs is necessary for the patient's health and well-being. The process of desensitization involves the careful and controlled administration of the drug in progressively larger doses, starting from a very small initial dose, which can be as minimal as one ten-thousandth of the target dose. This gradual increase in dosage is performed over a series of hours, allowing the patient's immune system to adjust and tolerate the medication without triggering a hypersensitivity response. Throughout the procedure, the patient is closely monitored for any adverse effects, ensuring immediate intervention if necessary. Additionally, the physician is responsible for documenting the entire process in a written report, which serves as a record of the procedure and the patient's response to the desensitization efforts.
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