CPT® Code 96405

CPT® Code 96405 refers to the administration of chemotherapy through intralesional injection, specifically targeting up to and including seven malignant lesions located in the skin or subcutaneous tissues. This procedure involves the injection of an anti-neoplastic agent, which is a type of medication designed to eradicate or reduce the size of cancerous lesions. The process begins with the cleansing of the skin surrounding the planned injection site to minimize the risk of infection. Following this, the physician carefully injects the anti-neoplastic agent directly into and around the malignant lesions. If multiple lesions are present, the physician will repeat the injection process for each lesion until all targeted areas have been treated. It is important to note that when coding for this procedure, the number of lesions treated is the determining factor for the appropriate code; thus, CPT® Code 96405 should be used for the injection of up to seven lesions, while CPT® Code 96406 is designated for cases involving more than seven lesions. This coding approach emphasizes that the focus is on the number of lesions rather than the number of injections, as a single lesion may require multiple injection sites for effective treatment.