CPT® Code 96521

The CPT® Code 96521 refers to the process of refilling and maintaining a portable pump that is utilized for the prolonged infusion of various therapeutic agents, including chemotherapy drugs, monoclonal antibodies, biologic response modifiers, and other antineoplastic substances. Prolonged infusion is specifically characterized as the administration of these substances over a duration exceeding eight hours. The portable pump is filled with a predetermined quantity of the medication, which is often complex in nature, and is programmed to deliver this medication continuously throughout the specified infusion period. It is essential to regularly check the functionality of the pump to ensure that it is operating correctly and that the medication is being dispensed as intended. For external portable pumps, the appropriate code to use is 96521, while 96522 should be used for implantable pumps or reservoirs.