Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot
Code deleted, see 11103, 11105, 11107

Official Description

each separate/additional lesion (List separately in addition to code for primary procedure)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 11101 is utilized for the biopsy of each separate or additional lesion beyond the primary procedure. This code is specifically designated for instances where multiple lesions are biopsied during a single patient encounter. The procedure involves the physician carefully cleansing the lesion, administering a local anesthetic to minimize discomfort, and then excising all or part of the lesion using a scalpel. The excised tissue is subsequently sent to a laboratory for histologic examination, which is essential for diagnosing various skin, subcutaneous, or mucous membrane conditions. After the biopsy, the site may be closed with sutures or left open to heal naturally, depending on the clinical judgment of the physician. It is important to note that CPT® Code 11100 should be used for the biopsy of a single lesion, while CPT® Code 11101 is reserved for each additional lesion that is biopsied during the same session.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 11101 is indicated for the biopsy of multiple skin, subcutaneous, or mucous membrane lesions. The specific indications for performing this procedure include:

  • Suspicious Lesions Lesions that exhibit characteristics suggestive of malignancy or other pathological conditions warranting histological evaluation.
  • Multiple Lesions Situations where a patient presents with more than one lesion that requires biopsy for diagnostic purposes.
  • Monitoring Changes Lesions that have changed in appearance, size, or symptoms over time, necessitating further investigation.

2. Procedure

The procedure for CPT® Code 11101 involves several critical steps to ensure accurate biopsy and subsequent analysis. The steps are as follows:

  • Step 1: Preparation The physician begins by preparing the patient and the biopsy site. This includes a thorough examination of the lesions to determine which ones will be biopsied. The area surrounding the lesion is cleansed with an antiseptic solution to minimize the risk of infection.
  • Step 2: Anesthesia A local anesthetic is then injected into the area around the lesion to ensure that the patient experiences minimal discomfort during the procedure. This step is crucial for patient comfort and cooperation.
  • Step 3: Lesion Excision Using a scalpel, the physician carefully excises all or a portion of the lesion. The technique may vary depending on the size and type of lesion, but the goal is to obtain a sufficient tissue sample for histological examination.
  • Step 4: Sample Handling Once the lesion is excised, the tissue sample is placed in a suitable container and sent to a laboratory for histologic examination. This analysis is vital for diagnosing any underlying conditions.
  • Step 5: Site Closure After the biopsy, the physician assesses the biopsy site. Depending on the size of the excised area, the site may be closed with sutures or left open to granulate. The decision on how to close the site is based on clinical judgment and the specific circumstances of the biopsy.

3. Post-Procedure

Post-procedure care for patients who have undergone a biopsy using CPT® Code 11101 includes monitoring the biopsy site for signs of infection, such as increased redness, swelling, or discharge. Patients are typically advised to keep the area clean and dry, and to follow any specific instructions provided by the physician regarding wound care. Additionally, patients should be informed about the expected healing process and when to return for follow-up appointments to discuss the results of the histologic examination. It is essential for patients to report any unusual symptoms or concerns during their recovery period.

Short Descr BIOPSY SKIN ADD-ON
Medium Descr BIOPSY SKIN SUBQ&/MUCOUS MEMBRANE EA ADDL LESN
Long Descr each separate/additional lesion (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6A - Minor procedures - skin
MUE Not applicable/unspecified.
CCS Clinical Classification 173 - Other diagnostic procedures on skin and subcutaneous tissue
Date
Action
Notes
2019-01-01 Deleted Code deleted, see 11103, 11105, 11107
2013-01-01 Changed Medium Descriptor changed.
2011-01-01 Changed Short description changed.
2004-01-01 Changed Code description changed.
Pre-1990 Added Code added.
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"