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Code deleted. See 80305, 80306, 80307.

Official Description

Drug screen, any number of drug classes from Drug Class List A; any number of non-TLC devices or procedures, (eg, immunoassay) capable of being read by direct optical observation, including instrumented-assisted when performed (eg, dipsticks, cups, cards, cartridges), per date of service

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80300 refers to a laboratory test designed to screen for the presence of various legal and illegal substances categorized under Drug Class List A. This test is primarily conducted using urine samples, although it may also be performed on blood, saliva, hair, and sweat. The substances included in Drug Class List A are diverse and encompass a range of drugs such as alcohol (ethanol), amphetamines, barbiturates, benzodiazepines, buprenorphine, cocaine and its metabolites, heroin and its metabolites, methadone and its metabolite EDDP, methamphetamine, methaqualone, methylenedioxymethamphetamine (MDMA), opiates, oxycodone, phencyclidine, propoxyphene, tetrahydrocannabinol (THC) metabolites, and tricyclic antidepressants. The initial screening process utilizes a competitive binding mechanism involving antibodies to detect the presence of a drug or its metabolite. This method is characterized by a predetermined cutoff level; any substance concentration below this threshold is interpreted as negative, while any concentration above it is considered positive. Among the substances most frequently tested are cannabinoids, cocaine, amphetamines/methamphetamines, opiates, and phencyclidine. The results from this rapid qualitative test can be obtained through direct optical observation of a dipstick or via a digital readout from advanced systems such as eCup or similar rapid cup/card systems. It is important to note that all positive results from this initial screening should be confirmed through a secondary testing method, such as gas chromatography/mass spectrometry, to accurately identify the specific substance present.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 80300 is indicated for use in various scenarios where screening for the presence of drugs is necessary. The following conditions or situations may warrant the performance of this drug screening test:

  • Substance Abuse Evaluation This test is often utilized in the assessment of individuals suspected of substance abuse, providing a preliminary indication of drug use.
  • Pre-Employment Screening Employers may require drug screening as part of the hiring process to ensure a drug-free workplace.
  • Monitoring Treatment Compliance Healthcare providers may use this test to monitor patients undergoing treatment for substance use disorders, ensuring adherence to prescribed therapies.
  • Legal and Forensic Testing The test may be employed in legal contexts, such as probation or custody cases, where drug use needs to be verified.
  • Emergency Room Assessments In emergency situations, this screening can help identify substances that may be affecting a patient's health and guide treatment decisions.

2. Procedure

The procedure for conducting the drug screening under CPT® Code 80300 involves several key steps, which are outlined as follows:

  • Sample Collection A urine sample is typically collected from the patient, although other biological samples such as blood, saliva, hair, or sweat may also be used depending on the clinical scenario and the substances being tested.
  • Initial Screening Test The collected sample undergoes an initial screening test using immunoassay techniques. This method employs competitive binding of antibodies to detect the presence of specific drugs or their metabolites in the sample.
  • Optical Observation The results of the screening are determined through direct optical observation, which may involve the use of dipsticks or digital readouts from instrumented systems like eCup or similar rapid cup/card systems.
  • Interpretation of Results The test results are interpreted based on predetermined cutoff levels. Any substance concentration below the cutoff is reported as negative, while concentrations above the cutoff are reported as positive.
  • Confirmation Testing For any positive results obtained from the initial screening, a confirmation test is required. This secondary test, typically performed using gas chromatography/mass spectrometry, accurately identifies the specific substances present in the sample.

3. Post-Procedure

After the drug screening procedure is completed, several post-procedure considerations should be taken into account. Patients may be informed of their results, particularly if they are negative, which may alleviate concerns regarding substance use. In cases of positive results, it is essential to communicate the need for confirmation testing to ensure accurate identification of substances. Additionally, healthcare providers should discuss the implications of the results with the patient, especially in contexts such as treatment compliance or legal matters. Follow-up actions may include referrals for counseling or treatment for substance use disorders, depending on the results and the patient's circumstances.

Short Descr DRUG SCREEN NON TLC DEVICES
Medium Descr DRUG SCREEN LIST A ANY NMBR NON TLC DEVICES
Long Descr Drug screen, any number of drug classes from Drug Class List A; any number of non-TLC devices or procedures, (eg, immunoassay) capable of being read by direct optical observation, including instrumented-assisted when performed (eg, dipsticks, cups, cards, cartridges), per date of service
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x)
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE Not applicable/unspecified.
Date
Action
Notes
2016-12-31 Deleted Code deleted. See 80305, 80306, 80307.
2015-01-01 Added Added
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