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Code deleted. See 80305, 80306, 80307.

Official Description

Drug screen, any number of drug classes from Drug Class List A; single drug class method, by instrumented test systems (eg, discrete multichannel chemistry analyzers utilizing immunoassay or enzyme assay), per date of service

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80301 refers to a laboratory test designed to detect a single drug class from Drug Class List A. This test is primarily performed on urine samples, although it can also be conducted on other biological specimens such as blood, saliva, hair, and sweat. Drug Class List A encompasses a variety of substances, including alcohol (ethanol), amphetamines, barbiturates, benzodiazepines, buprenorphine, cocaine (and its metabolites), heroin (and its metabolites), methadone (including its metabolite EDDP), methamphetamine, methaqualone, methylenedioxymethamphetamine (MDMA), opiates, oxycodone, phencyclidine, propoxyphene, tetrahydrocannabinol (THC), and tricyclic antidepressants. The test utilizes instrumented test systems, such as discrete multichannel chemistry analyzers, which employ immunoassay or enzyme assay methods to perform the analysis. These analyzers can be programmed to include or exclude specific tests based on clinical necessity, allowing for a tailored approach to drug screening. This method provides a cost-effective and accurate means for preliminary drug testing, delivering rapid qualitative results that can assist healthcare providers in making informed decisions regarding patient care.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 80301 is indicated for use in various clinical scenarios where drug screening is necessary. The following conditions or situations may warrant the performance of this test:

  • Substance Abuse Evaluation This test is often utilized in the assessment of individuals suspected of substance abuse, providing critical information regarding the presence of specific drugs in their system.
  • Pre-employment Screening Employers may require drug screening as part of the hiring process to ensure a drug-free workplace.
  • Monitoring Treatment Compliance Healthcare providers may use this test to monitor patients undergoing treatment for substance use disorders, ensuring adherence to prescribed regimens.
  • Legal and Forensic Testing The test may be employed in legal contexts, such as probation monitoring or custody disputes, where drug use is a relevant factor.

2. Procedure

The procedure for conducting the drug screen under CPT® Code 80301 involves several key steps, which are outlined below:

  • Sample Collection A biological specimen, typically urine, is collected from the patient. In some cases, other specimens such as blood, saliva, hair, or sweat may be used depending on the clinical requirements.
  • Preparation of the Analyzer The discrete multichannel chemistry analyzer is prepared for testing. This involves programming the analyzer to include or exclude specific drug classes from Drug Class List A based on clinical necessity.
  • Testing Process The collected specimen is subjected to an immunoassay or enzyme assay method within the analyzer. This process allows for the qualitative determination of the presence of the selected drug class in the specimen.
  • Result Interpretation Once the analysis is complete, the results are interpreted. The analyzer provides rapid qualitative results indicating whether the specific drug class is present in the sample.
  • Reporting The findings are documented and reported to the requesting healthcare provider, who will use the information to guide further clinical decisions.

3. Post-Procedure

After the completion of the drug screening procedure, the following post-procedure considerations should be noted:

Patients may be advised on the interpretation of their results, especially if a positive result is obtained. It is important for healthcare providers to discuss the implications of the findings with the patient, including potential follow-up testing or treatment options. Additionally, the results should be integrated into the patient's overall clinical assessment to ensure comprehensive care. In cases where further testing is required, such as confirmatory testing for positive results, appropriate referrals or additional laboratory tests should be arranged. Overall, the post-procedure phase is crucial for ensuring that the results are utilized effectively in the patient's treatment plan.

Short Descr DRUG SCREEN CLASS LIST A
Medium Descr DRUG SCREEN LIST A SINGLE DRUG CLASS METHOD
Long Descr Drug screen, any number of drug classes from Drug Class List A; single drug class method, by instrumented test systems (eg, discrete multichannel chemistry analyzers utilizing immunoassay or enzyme assay), per date of service
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x)
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE Not applicable/unspecified.
Date
Action
Notes
2016-12-31 Deleted Code deleted. See 80305, 80306, 80307.
2015-01-01 Added Added
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