CPT® Code 85378

The CPT® Code 85378 refers to the qualitative or semiquantitative testing of fibrin degradation products, specifically focusing on D-dimer. D-dimer testing is a crucial laboratory procedure utilized primarily to assist in ruling out the presence of a thrombus, which is a blood clot that can obstruct blood flow. The significance of D-dimer lies in its negative predictive value; a negative result from this test indicates that there are no elevated levels of fibrin degradation products in the specimen, suggesting that a thrombus is unlikely. Conversely, a positive result signifies an abnormally high concentration of fibrin degradation products, which may suggest the presence of a thrombus. This test is particularly valuable in diagnosing conditions such as deep vein thrombophlebitis, pulmonary embolism, and stroke. Additionally, D-dimer testing is employed to evaluate hypercoagulability, a condition that increases the risk of blood clots, and to assist in diagnosing disseminated intravascular coagulation (DIC). Furthermore, it can be used to monitor the effectiveness of treatment for DIC. It is important to note that while CPT® Code 85378 encompasses qualitative and semiquantitative testing methodologies, it is distinct from CPT® Code 85379, which involves a quantitative assessment providing specific levels of fibrin degradation products. The testing methodology associated with CPT® Code 85378 is less sensitive compared to that of CPT® Code 85380, which is designed for ultrasensitive testing, yielding rapid and highly accurate results due to its enhanced sensitivity.