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Official Description

Heparin-protamine tolerance test

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 85530 refers to the Heparin-protamine tolerance test, which is a laboratory procedure designed to evaluate the body's response to heparin and protamine. Heparin is a widely used anticoagulant medication that plays a crucial role in preventing and treating blood clots by inhibiting the formation of fibrin, a key component in blood clotting. Protamine, on the other hand, is a medication that acts as a reversal agent for heparin; it binds to heparin molecules, effectively neutralizing their anticoagulant effects. The heparin-protamine tolerance test is particularly important in clinical settings where patients are undergoing heparin therapy, as it helps to determine how well a patient can tolerate the administration of protamine after heparin treatment. This test is essential for ensuring patient safety and effective management of anticoagulation therapy, especially in situations where rapid reversal of heparin is necessary, such as during surgical procedures or in cases of heparin overdose.

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