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Official Description

Blood typing, serologic; antigen screening for compatible unit using patient serum, per unit screened

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Blood typing, serologic, is a critical laboratory procedure that involves the screening of donated blood units to ensure compatibility with a recipient's blood type before a transfusion. This process is essential to prevent adverse reactions that can occur if incompatible blood is transfused. The procedure specifically focuses on identifying the antibodies present in the donated blood, which can interact negatively with the recipient's immune system. In situations where time is of the essence, such as emergencies, a serum test may be performed instead of a more comprehensive antibody test. The CPT® Code 86904 is designated for this specific serologic blood typing procedure, indicating that it is performed per unit of blood screened. This ensures that each unit of blood is evaluated for compatibility, thereby enhancing patient safety during transfusions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Blood typing, serologic, is indicated in various clinical scenarios where blood transfusions are necessary. The following conditions warrant the performance of this procedure:

  • Blood Transfusion Blood typing is performed to ensure that the blood units being transfused are compatible with the recipient's blood type, thereby preventing hemolytic reactions.
  • Emergency Situations In urgent cases where there is insufficient time to conduct a full antibody test, a serum test using CPT® Code 86904 is utilized to quickly assess compatibility.
  • Preoperative Assessment Prior to surgical procedures that may require blood transfusions, blood typing is conducted to prepare for potential transfusion needs.

2. Procedure

The procedure for blood typing, serologic, involves several key steps to ensure accurate screening of blood units. Each step is crucial for determining compatibility:

  • Step 1: Sample Collection A blood sample is collected from the patient, typically via venipuncture, to obtain serum for testing. This sample is essential for identifying any antibodies that may react with the donor blood.
  • Step 2: Serum Preparation The collected blood sample is processed to separate the serum from the cellular components. This serum is then used for the antigen screening process.
  • Step 3: Antigen Screening The serum is tested against the antigens present in the donated blood units. This step involves mixing the serum with the blood units to observe any reactions that may indicate incompatibility.
  • Step 4: Interpretation of Results The results of the antigen screening are analyzed to determine if the blood unit is compatible with the patient’s blood type. Any positive reactions indicate the presence of antibodies that could lead to transfusion reactions.

3. Post-Procedure

After the blood typing procedure is completed, the results are documented and communicated to the healthcare team. If the blood unit is found to be compatible, it can be prepared for transfusion. In cases where incompatibility is detected, alternative blood units must be sourced. It is also important to monitor the patient for any adverse reactions during and after the transfusion process. Proper documentation of the blood typing results is essential for compliance and future reference.

Short Descr BLOOD TYPING PATIENT SERUM
Medium Descr BLOOD TYPING ANTIGEN SCREEN PATIENT SERUM/UNIT
Long Descr Blood typing, serologic; antigen screening for compatible unit using patient serum, per unit screened
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator STV-Packaged Codes
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
Date
Action
Notes
2015-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
1993-01-01 Added First appearance in code book in 1993.
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