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The CPT® Code 87450 refers to a laboratory test designed to detect infectious agent antigens in blood and other body fluids through the use of immunoassay techniques. This code encompasses various methodologies, including enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), and immunochemiluminometric assay (IMCA). These techniques are pivotal in clinical diagnostics as they utilize labeled antibodies to identify specific antigens present in patient samples. The EIA and ELISA methods are particularly sensitive, capable of detecting minute quantities of antigens due to the incorporation of a secondary enzyme-labeled antibody. This enzyme catalyzes a reaction that results in a color change or fluorescence, allowing for qualitative or semiquantitative assessment of the infectious agent's presence. On the other hand, IMCA employs a light emission device to quantify the antigen-antibody complex, providing a more precise measurement of the infectious agent. The testing can be performed using a single-step method, where the labeled antibody is added to the sample, followed by a wash and examination, or a multi-step method that involves several washes and additional labeled antibodies. It is important to note that this code specifically applies to the single-step method for each organism that is not otherwise specified (NOS), distinguishing it from other related codes that may involve multi-step methods or multiple organisms.
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The CPT® Code 87450 is indicated for use in the detection of infectious agent antigens in various clinical scenarios. The following conditions may warrant the use of this test:
The procedure for CPT® Code 87450 involves several key steps to ensure accurate detection of infectious agent antigens:
After the procedure associated with CPT® Code 87450, the laboratory will analyze the results and report the findings. The expected outcome is a qualitative or semiquantitative result indicating the presence or absence of the infectious agent antigen. Clinicians may use these results to guide further diagnostic or therapeutic decisions. It is essential for healthcare providers to interpret the results in conjunction with clinical findings and other diagnostic tests. Additionally, any necessary follow-up testing or treatment adjustments should be discussed with the patient based on the results obtained from this immunoassay technique.
| Short Descr | AG DETECT NOS IA SINGLE | Medium Descr | IAAD IA SINGLE STEP METHOD NOS EA ORGANISM | Long Descr | Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], immunochemiluminometric assay [IMCA]), qualitative or semiquantitative; single step method, not otherwise specified, each organism | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | Not applicable/unspecified. | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2022-01-01 | Deleted | First appearance of deletion in codebook. |
| 2021-01-01 | Deleted | First appearance of deletion in CPT® Code Set. |
| 2021-01-01 | Changed | Code description changed. |
| 2020-10-05 | Deleted | Code deleted. |
| 2020-10-01 | Deleted | Code deleted, see 87301-87451, 87802-87899 |
| 2016-01-01 | Changed | Description Changed |
| 2011-01-01 | Changed | Short description changed. |
| 2001-01-01 | Changed | Code description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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