© Copyright 2026 American Medical Association. All rights reserved.
CPT® Code 88161 refers to a specific laboratory test within the field of cytopathology, which involves the preparation, screening, and interpretation of smears derived from various sources. This procedure is essential for diagnosing a range of conditions, including malignant and premalignant diseases, infections, autoimmune disorders, inflammation, immune reactions, cellular aging, and amyloidosis. Cytopathology itself is the microscopic examination of cells that either naturally shed from tissues or can be collected from body surfaces through methods such as washing or brushing. The process begins with obtaining a sample, which is typically done through a separate, reportable procedure. Once the sample is collected, a technician or pathologist prepares the slide(s) for examination. The pathologist then meticulously analyzes the prepared slide(s) under a microscope, ultimately generating a comprehensive written report detailing the findings. It is important to note that while Code 88160 is designated for screening and interpretation of samples, Code 88161 specifically applies when the sample necessitates preparation prior to the screening and interpretation process. Additionally, Code 88162 is utilized for cases requiring an extended study involving more than five slides and/or multiple staining techniques.
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