CPT® Code 88363

Examination and selection of retrieved archival (ie, previously diagnosed) tissue(s) for molecular analysis (eg, KRAS mutational analysis)

The CPT® Code 88363 refers to the examination and selection of previously diagnosed tissue samples for the purpose of conducting molecular analysis. This procedure involves retrieving archival tissues that have already undergone an initial examination and diagnosis. The primary goal of this process is to gather further insights into a neoplasm or other disease processes, which can significantly aid in formulating an effective treatment regimen. Molecular analysis encompasses a variety of tests aimed at investigating chromosomes, chromosome mutations, genes, and gene mutations that play a crucial role in disease states and can influence treatment outcomes. A notable example of this type of analysis is the KRAS mutational analysis, which is particularly relevant for patients diagnosed with specific malignancies. This analysis seeks to identify mutations in the KRAS gene, which are often linked to a poor prognosis or a limited response to therapies that target the epidermal growth factor receptor (EGFR) pathway. The EGFR pathway is a complex network of signals that are integral to the development and growth of cancer, making the insights gained from this molecular analysis vital for tailoring patient-specific treatment strategies.