CPT® Code 88387

Macroscopic examination, dissection, and preparation of tissue for non-microscopic analytical studies (eg, nucleic acid-based molecular studies), each tissue preparation (eg, a single lymph node)

The CPT® Code 88387 refers to the macroscopic examination, dissection, and preparation of tissue specifically for non-microscopic analytical studies, such as nucleic acid-based molecular studies. This procedure involves a thorough visual examination of the tissue sample, where definitive characteristics are noted to assess the sample's quality and relevance. Following this examination, the tissue undergoes dissection, which allows for a more detailed evaluation of its structure and composition. The preparation of the tissue is a critical step, where it can be fixed using either an aldehyde or alcohol fixator, or alternatively, it may be frozen to preserve its integrity for further analysis. Once prepared, the tissue is embedded in a medium such as paraffin or resin, which facilitates the slicing of the tissue into thin sections. These sections are essential for conducting non-microscopic analytical studies, particularly those that focus on nucleic acids. Such studies are often performed on patients with specific diseases that may be linked to genetic mutations, as well as on malignant neoplasms. The range of molecular studies that can be conducted is broad and is determined by the patient's diagnosis or the suspected disease. After the analytical studies are completed, the physician interprets the results and compiles a written report detailing the findings, which is crucial for guiding further clinical decisions and treatment options.