CPT® Code 90664

The CPT® Code 90664 refers to the influenza virus vaccine, specifically a live attenuated influenza virus (LAIV) vaccine that is formulated for intranasal use. This vaccine contains a weakened form of the live influenza virus, which is designed to stimulate the immune system without causing the disease. The pandemic formulation of this vaccine may differ from the standard interpandemic strains, incorporating specific additives known as adjuvants that enhance the immune response by increasing the antigen content. These formulations are crucial during an influenza pandemic, which occurs when a novel strain of the influenza virus emerges and spreads among the human population, often resulting in significant morbidity and mortality due to the lack of pre-existing immunity in the population. The intranasal administration of LAIV is particularly effective as it targets the mucosal immune system in the nasal passages, prompting the body to produce antibodies against the influenza virus. Notably, LAIV is cold-adapted and temperature-sensitive, meaning that it replicates effectively only in the cooler environment of the nose and throat, preventing it from spreading to the upper respiratory tract where the temperature is higher. This code is specifically designated for the vaccine product itself, and it is important to report the intranasal administration of the vaccine separately to ensure accurate billing and coding practices.