© Copyright 2026 American Medical Association. All rights reserved.
An inactivated quadrivalent influenza virus vaccine (IIV4) is designed for intramuscular administration, specifically formulated to provide protection against four distinct strains of the influenza virus. This vaccine is unique in that it offers active, long-term immunity by exposing the recipient's immune system to modified versions of the influenza viruses. Unlike immune globulins, which provide temporary, passive immunity, vaccines stimulate the immune system to produce its own antibodies, enabling the body to recognize and combat the actual viruses upon future exposure. The manufacturing process of this vaccine involves the use of embryonated chicken eggs, where the influenza virus is cultivated, harvested, and subsequently inactivated using formaldehyde. Following this, the virus is concentrated and purified to ensure safety and efficacy. An adjuvant is incorporated into the vaccine formulation to enhance the immune response, making the vaccine more effective. The quadrivalent formulation specifically targets two different strains of influenza type A and two strains of influenza type B, providing broader protection against circulating influenza viruses. It is important to note that when reporting this vaccine, code 90689 should be used for the 0.25 mL dosage administered intramuscularly, while the actual injection procedure should be reported separately.
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