© Copyright 2026 American Medical Association. All rights reserved.
CPT® Code 96422 refers to the administration of chemotherapy through an intra-arterial infusion technique, specifically for a duration of up to one hour. This method is utilized primarily for the treatment of malignant neoplasms, which are cancerous tumors that can invade surrounding tissues and spread to other parts of the body. Intra-arterial infusion is a specialized technique that allows for the direct delivery of chemotherapy agents to the artery supplying blood to the affected organ or tumor site. This targeted approach can enhance the effectiveness of the treatment while potentially minimizing systemic side effects associated with traditional intravenous chemotherapy. The procedure may also be known as regional or isolation chemotherapy perfusion, emphasizing its focus on delivering high concentrations of the drug directly to the tumor. It is important to note that this procedure typically requires the performance of arterial catheterization under radiologic supervision to ensure accurate placement of the catheter for effective drug delivery. For billing purposes, CPT® Code 96422 is specifically designated for the initial hour of infusion, with additional codes available for extended durations of treatment.
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