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Official Description

Chemotherapy administration, intra-arterial; infusion technique, each additional hour (List separately in addition to code for primary procedure)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

CPT® Code 96423 refers to the administration of chemotherapy via an intra-arterial infusion technique, specifically for each additional hour of treatment beyond the initial hour. This method is utilized primarily for the treatment of malignant neoplasms, where a chemotherapy substance or drug is delivered directly into the artery that supplies blood to the affected organ or site. The intra-arterial infusion technique, also known as regional or isolation chemotherapy perfusion, allows for a concentrated delivery of the chemotherapy agent directly to the tumor, potentially increasing its effectiveness while minimizing systemic exposure. The procedure typically involves the use of arterial catheterization, which is performed under radiologic supervision to ensure accurate placement of the catheter for optimal drug delivery. It is important to note that this code is used as an add-on to the primary procedure code for the initial hour of infusion, which is reported using CPT® Code 96422. For cases requiring prolonged chemotherapy administration beyond eight hours, CPT® Code 96425 should be utilized, which accounts for the use of a portable or implantable pump for the infusion process.

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