CPT® Code 96425

Chemotherapy administration, intra-arterial; infusion technique, initiation of prolonged infusion (more than 8 hours), requiring the use of a portable or implantable pump

The CPT® Code 96425 refers to the administration of chemotherapy through an intra-arterial infusion technique, specifically for prolonged infusions that last more than eight hours. This method is particularly utilized in the treatment of malignant neoplasms, where a chemotherapy substance or drug is delivered directly into the artery supplying blood to the affected organ or site. This targeted approach, often termed regional or isolation chemotherapy perfusion, allows for a higher concentration of the chemotherapy agent to reach the tumor while minimizing systemic exposure and potential side effects. The procedure necessitates the use of a portable or implantable pump to facilitate the extended duration of the infusion. Prior to the infusion, a separate arterial catheterization is performed under radiologic supervision to ensure accurate delivery of the chemotherapy directly to the neoplasm. This code is specifically designated for cases where the infusion exceeds eight hours, distinguishing it from shorter infusion codes such as 96422, which covers intra-arterial infusions lasting up to one hour, and 96423, which is an add-on code for each additional hour of infusion beyond the first hour.