© Copyright 2026 American Medical Association. All rights reserved.
Percutaneous electrical nerve field stimulation (PENFS), also referred to as auricular neurostimulation, is a non-invasive therapeutic procedure designed specifically for pediatric patients aged 11 to 18 who are suffering from non-resolving abdominal pain related to irritable bowel syndrome (IBS). This innovative treatment approach was developed based on research indicating that certain IBS patients exhibit abnormal activity in the amygdala, a critical region of the brain responsible for regulating the autonomic nervous system, which plays a significant role in pain perception and response. During the PENFS procedure, electrodes are strategically placed in and around the external ear to deliver targeted electrical stimulation to the cranial nerve bundles. This stimulation aims to modify the transmission of pain signals, thereby reducing the sensitivity to abdominal pain experienced by the patient. A small, battery-operated electrical generator is positioned behind the ear to facilitate this stimulation. The treatment regimen typically involves administering PENFS for a total of 120 hours per week over a maximum duration of three consecutive weeks. While PENFS is generally considered safe, patients may experience mild side effects such as ear discomfort or an allergic reaction to the adhesive used for electrode placement. It is important to note that PENFS is contraindicated in individuals with certain medical conditions, including those who have cardiac pacemakers, hemophilia, or psoriasis. Additionally, this treatment may be utilized in conjunction with other therapeutic interventions to enhance overall patient care.
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