CPT® Code 0748T

Injections of stem cell product into perianal perifistular soft tissue, including fistula preparation (eg, removal of setons, fistula curettage, closure of internal openings)

The procedure described by CPT® Code 0748T involves the injection of a stem cell product into the perianal perifistular soft tissue, specifically targeting the treatment of perianal fistulas. These fistulas often arise as a complication of Crohn’s disease, a chronic inflammatory bowel condition. The use of mesenchymal stem cells, which can be sourced from either bone marrow or adipose tissue, is integral to this treatment. One such product, Darvadstrocel (Alofisel), is utilized for its therapeutic properties, which include the ability to mitigate inflammatory responses, enhance T cell formation, and differentiate into fibroblasts. This differentiation is crucial as it aids in the formation of a healing scar within the fistula, promoting closure and recovery. Prior to the injection, the physician prepares the fistula site, which may involve the removal of setons, curettage of the fistula tract, or closure of any internal openings that connect the fistula to surrounding tissues. This preparation is essential to ensure the effectiveness of the stem cell injection and to optimize the healing process.