© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 38210 refers to the process of transplant preparation of hematopoietic progenitor cells, specifically focusing on the depletion of T-cells during the harvesting of these cells. Hematopoietic progenitor cells are essential for the formation of blood cells and are often harvested from blood for use in transplantation procedures. The depletion of T-cells is a critical step in this process, particularly for allogeneic transplants, where the donor and recipient are different individuals. This procedure aims to minimize the risk of graft-versus-host disease (GVHD), a condition where the transplanted immune cells attack the recipient's body. During the harvesting process, the collected blood is processed through an automated device designed to selectively remove T-cells and other unwanted cells, ensuring that the final product is enriched with the desired progenitor cells. Following the depletion process, a quality assessment is conducted to verify that the T-cells and other undesired cells have been adequately removed, confirming the suitability of the transplant product for future transplantation. Additionally, any necessary cryopreservation and storage of the harvested cells are performed as a separate reportable service, ensuring that the cells remain viable until they are needed for the transplant procedure.
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