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Official Description

Hemoglobin; sulfhemoglobin, qualitative

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Sulfhemoglobinemia is a rare hematological condition characterized by the incorporation of sulfur atoms into the hemoglobin molecule, which impairs the red blood cells' ability to effectively bind and transport oxygen throughout the body. This condition is typically associated with an overdose of medications that contain sulfonamides or with occupational exposure to sulfur compounds. The presence of sulfhemoglobin in the blood can lead to significant health issues due to the reduced oxygen-carrying capacity of the affected red blood cells. To diagnose this condition, a blood sample is collected through a procedure known as venipuncture, which is separately reportable. The CPT® Code 83055 specifically refers to a qualitative blood test that is conducted to ascertain whether sulfhemoglobin is present in the sample. This test is distinct from CPT® Code 83060, which involves a quantitative assessment of sulfhemoglobin levels in whole blood using spectrophotometry. The qualitative test serves as an initial screening tool to identify the presence of sulfhemoglobin, guiding further diagnostic and therapeutic decisions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Testing for sulfhemoglobin is indicated in specific clinical scenarios where sulfhemoglobinemia is suspected. The following conditions may warrant the performance of this test:

  • Medication Overdose An overdose of sulfonamide-containing medications may lead to the formation of sulfhemoglobin, necessitating testing to confirm the diagnosis.
  • Occupational Exposure Individuals who have been exposed to sulfur compounds in their work environment may develop sulfhemoglobinemia, prompting the need for testing to evaluate their hemoglobin status.
  • Unexplained Cyanosis Patients presenting with unexplained cyanosis or hypoxia may require sulfhemoglobin testing to determine if sulfhemoglobinemia is the underlying cause of their symptoms.

2. Procedure

The procedure for testing sulfhemoglobin involves several key steps that ensure accurate results. First, a qualified healthcare professional performs venipuncture to obtain a blood sample from the patient. This step is crucial as it provides the necessary specimen for analysis. Once the blood sample is collected, it is sent to a laboratory where the qualitative test for sulfhemoglobin is conducted. The laboratory personnel will utilize specific reagents and techniques to determine the presence of sulfhemoglobin in the sample. The qualitative nature of this test means that it will indicate whether sulfhemoglobin is present or absent, rather than measuring the exact concentration of sulfhemoglobin in the blood. This initial screening is essential for diagnosing sulfhemoglobinemia and may lead to further testing if sulfhemoglobin is detected.

3. Post-Procedure

After the procedure, there are generally no specific post-procedure care requirements for the patient, as the venipuncture site may be bandaged to prevent bleeding. Patients are typically advised to monitor the site for any signs of excessive bleeding or infection. If sulfhemoglobin is detected in the qualitative test, further evaluation and management may be necessary, which could include additional testing to quantify sulfhemoglobin levels or to assess the patient's overall hemoglobin status. It is important for healthcare providers to communicate the results of the test to the patient and discuss any necessary follow-up actions based on the findings.

Short Descr BLOOD SULFHEMOGLOBIN TEST
Medium Descr HEMOGLOBIN SULFHEMOGLOBIN QUALITATIVE
Long Descr Hemoglobin; sulfhemoglobin, qualitative
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2015-01-01 Deleted Code deleted
Pre-1990 Added Code added.
Code
Description
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