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Official Description

Nicotine

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83887 refers to a laboratory test specifically designed to measure nicotine levels in the body. This test can be performed using either a blood or urine sample, providing flexibility in sample collection methods. Nicotine, an alkaloid derived from plants in the nightshade family, is most commonly associated with tobacco products. The presence of nicotine in the body can indicate recent tobacco use, and measuring its levels can be crucial for various clinical assessments. The blood sample is obtained through a procedure known as venipuncture, which involves puncturing a vein to collect blood, while the urine sample is collected through a random void, meaning it is taken at any time without prior preparation. The analysis of both blood and urine samples is conducted using a sophisticated technique called quantitative liquid chromatography-tandem mass spectrometry, which allows for precise measurement of nicotine concentrations. This test is essential for healthcare providers to evaluate exposure to nicotine and to assist in smoking cessation programs or other related health assessments.

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