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Official Description

Methadone

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83840 refers to a laboratory test specifically designed to measure the levels of methadone in various biological samples, including blood, urine, or meconium stool. Methadone is classified as a synthetic opioid, which means it is a man-made substance that mimics the effects of natural opiates. It is primarily utilized in the management of moderate to severe chronic pain and plays a crucial role in treating individuals undergoing withdrawal from other opiate drugs. The testing process involves obtaining a sample, which can be collected through venipuncture for blood, or through a random voided urine sample, or from meconium stool collected from a newborn's diaper. The analysis of these samples is conducted using a sophisticated technique known as quantitative liquid chromatography-tandem mass spectrometry, which allows for precise measurement of methadone levels in the tested specimens. This test is essential for monitoring therapeutic levels of methadone in patients, ensuring effective pain management, and preventing potential overdose or withdrawal symptoms.

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