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Official Description

Fc receptor

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Fc receptor testing is a diagnostic procedure aimed at identifying specific proteins known as Fc receptors, which play a crucial role in the immune system's defense mechanisms. These receptors are located on the surface of various immune cells, including natural killer cells, macrophages, neutrophils, and mast cells. The primary function of Fc receptors is to bind to antibodies that are attached to infecting cells or pathogens, thereby facilitating the immune response. This binding action triggers processes such as phagocytosis or cytotoxic destruction of microbes, which are essential for maintaining the body's defense against infections. There are three distinct types of Fc receptors: Fc-gamma, Fc-alpha, and Fc-epsilon. Fc-gamma receptors belong to the immunoglobulin superfamily and are instrumental in inducing the phagocytosis of microbes that have been opsonized, or marked, by antibodies. Fc-alpha receptors are present on various white blood cells, including neutrophils, eosinophils, monocytes, certain macrophages (such as Kupffer cells), and dendritic cells, contributing to the immune response. Fc-epsilon receptors, which have both high and low affinity variants, are found on cells such as epidermal Langerhans cells, eosinophils, mast cells, and basophils. The high-affinity Fc-epsilon receptors are particularly active during allergic responses and are also present on antigen-presenting cells that produce cytokines, while the low-affinity variants regulate B cell growth and inhibit IgE binding on eosinophils, monocytes, and basophils. Overall, Fc receptor testing is vital for understanding immune function and diagnosing various immunological conditions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Fc receptor testing is indicated for various clinical scenarios where understanding the immune response is crucial. The following conditions may warrant this testing:

  • Immune System Disorders Testing may be performed to evaluate patients with suspected immune deficiencies or dysregulations that affect the body's ability to respond to infections.
  • Allergic Reactions This test can help in assessing the role of Fc-epsilon receptors in allergic responses, particularly in patients experiencing severe allergies or asthma.
  • Autoimmune Diseases Fc receptor testing may be indicated in the diagnosis and management of autoimmune conditions where the immune system mistakenly attacks the body's own tissues.
  • Infectious Diseases The test can be useful in understanding the immune response to specific pathogens, especially in cases of recurrent infections.

2. Procedure

The procedure for Fc receptor testing involves several key steps to ensure accurate results. The following outlines the procedural steps:

  • Step 1: Sample Collection A blood sample is collected from the patient, typically via venipuncture. This sample serves as the basis for testing the presence and levels of Fc receptors on immune cells.
  • Step 2: Laboratory Processing The collected blood sample is processed in a laboratory setting. This may involve separating the plasma from the blood cells to isolate the immune cells that express Fc receptors.
  • Step 3: Testing Methodology Various laboratory techniques, such as flow cytometry or enzyme-linked immunosorbent assay (ELISA), may be employed to detect and quantify the Fc receptors on the surface of the immune cells. These methods allow for precise measurement of receptor levels and functionality.
  • Step 4: Data Analysis The results obtained from the testing are analyzed by laboratory professionals. They assess the levels of Fc receptors and their implications for the patient's immune status.
  • Step 5: Reporting Results Finally, the findings are compiled into a report that is sent to the requesting physician, who will interpret the results in the context of the patient's clinical condition.

3. Post-Procedure

After the Fc receptor testing procedure, there are generally no specific post-procedure care requirements for the patient. However, it is important for the healthcare provider to discuss the results with the patient once they are available. Patients may be advised to monitor for any symptoms related to their immune system or underlying conditions. Follow-up appointments may be scheduled to review the test results and determine any necessary further actions or treatments based on the findings. Additionally, patients should be informed about the importance of maintaining regular health check-ups, especially if they have underlying immune system concerns.

Short Descr FC RECEPTOR
Medium Descr FC RECEPTOR
Long Descr Fc receptor
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 235 - Other Laboratory
Date
Action
Notes
2017-12-31 Deleted Code deleted.
Pre-1990 Added Code added.
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