CPT® Code 86378

Deleted

The CPT® Code 86378 refers to the Migration Inhibitory Factor (MIF) test, which is a laboratory procedure designed to measure the levels of migration inhibitory factor in the body. MIF is a type of macrophage-derived inflammatory cytokine that plays a crucial role in the immune response. It binds to specific immune cells, including CD74, to initiate an acute immune reaction. The release of MIF is stimulated by various factors, including bacterial antigens and glucocorticoids, as well as by the anterior pituitary gland in response to trauma. This test evaluates the production of lymphocytes when exposed to common antigens such as streptokinase-streptodornase, candida antigen, PPD (purified protein derivative), concanavalin A, phytohemagglutinin, and pokeweed. The results of the MIF test can provide valuable insights into a patient's immune competence and the presence of delayed-type hypersensitivity reactions. Notably, low or absent levels of MIF may indicate underlying immunodeficiency syndromes, including conditions such as AIDS, DiGeorge syndrome, or Wiskott-Aldrich syndrome, highlighting the test's significance in assessing immune function.