CPT® Code 87260

The CPT® Code 87260 refers to a laboratory test specifically designed for the detection of adenovirus antigens using an immunofluorescent technique. Adenoviruses are a group of more than 50 viruses that can cause a variety of illnesses in humans, categorized into six distinct species (A-F). These viruses are known to lead to conditions such as gastroenteritis, respiratory illnesses (including colds, croup, bronchitis, and pneumonia), conjunctivitis, hemorrhagic cystitis, and skin rashes. The test is performed on respiratory or fecal samples, which can be collected through various methods. For respiratory samples, collection techniques include nasopharyngeal swabs, aspirates, or washings, as well as bronchoalveolar lavage (BAL) or tracheal aspirates. Fecal samples can be obtained via rectal swabs or stool sampling. During the test, the collected sample is inoculated with antibodies that are specifically conjugated to fluorescein isothiocyanate, a fluorescent dye. The sample is then examined under an epifluorescence microscope. If adenovirus antigens are present, the antibodies will bind to these antigens, resulting in a bright green fluorescence in the cytoplasm and/or nuclei of the infected cells. In contrast, non-infected surrounding cells will exhibit a dull red fluorescence. This immunofluorescent test is valuable for diagnosing acute adenoviral infections and can also help identify asymptomatic carriers, as active adenovirus can be shed in respiratory secretions and feces for extended periods, sometimes lasting weeks or months.