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Official Description

Cytopathology, slides, cervical or vaginal; with manual screening and computer-assisted rescreening using cell selection and review under physician supervision

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 88154 refers to a specific cytopathology procedure involving the examination of cervical or vaginal slides. This procedure is commonly known as a Papanicolaou (PAP) smear, which is a critical test used to screen for cervical cancer and other abnormalities in the cervical cells. The test is designed to identify any changes in the cell structure that may indicate the presence of disease, such as cervical dysplasia or in situ carcinoma. Early detection through this screening allows for timely monitoring and treatment, potentially preventing the progression to invasive malignant disease.

During the procedure, cells are collected from the endocervix using a specialized instrument, such as a brush or stick. The collected specimen is then smeared onto a glass slide, fixed with a spray or immersion solution, and subsequently covered with a coverslip. This prepared slide is sent to a cytology laboratory, where it undergoes staining to enhance visibility under a microscope. A trained technician screens the slide for any abnormalities, identifying abnormal cells or clusters that may require further investigation.

The process outlined in CPT® Code 88154 includes both manual screening and computer-assisted rescreening. Initially, a technician performs a manual screening of the slide under the supervision of a physician. Following this, the slide is subjected to computer-assisted rescreening, where the computer is programmed to detect suspicious single cells and abnormal cell structures. The technician then reviews the findings generated by the computer, compares them with the manual screening results, and interprets both sets of findings. If any abnormalities are detected, the results may be referred to a pathologist for further review and interpretation, with findings communicated to the treating physician for appropriate follow-up actions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 88154 is indicated for the following conditions:

  • Cervical Dysplasia - The test is performed to detect precancerous changes in cervical cells.
  • In Situ Carcinoma - It helps identify early-stage cancer that has not yet invaded surrounding tissues.
  • Routine Screening - The PAP smear is a standard procedure for cervical cancer screening in women, typically recommended at regular intervals.

2. Procedure

The procedure for CPT® Code 88154 involves several key steps that ensure accurate screening and diagnosis:

  • Step 1: Specimen Collection - Cells are collected from the endocervix using a specialized instrument, such as a brush or stick. This step is crucial for obtaining a representative sample of cervical cells for examination.
  • Step 2: Slide Preparation - The collected specimen is smeared onto a glass slide. The slide is then fixed using a spray or immersion solution to preserve the cellular structure for microscopic examination.
  • Step 3: Staining - The prepared slide is sent to a cytology laboratory, where it undergoes staining. This process enhances the visibility of the cells under a microscope, allowing for better identification of abnormalities.
  • Step 4: Manual Screening - A trained technician performs a manual screening of the slide under the supervision of a physician. This initial screening involves a thorough examination of the slide for any abnormal cells or cell clusters.
  • Step 5: Computer-Assisted Rescreening - Following the manual screening, the slide is subjected to computer-assisted rescreening. The computer is programmed to identify suspicious single cells and abnormal cell structures, which aids in the detection of potential issues.
  • Step 6: Review and Interpretation - The technician reviews the findings from the computer-assisted screening, carefully examining the pinpointed abnormalities. These findings are then compared with the results of the manual screening, and the technician interprets both sets of findings to provide a comprehensive assessment.

3. Post-Procedure

After the completion of the procedure associated with CPT® Code 88154, the findings are communicated to the treating physician. If any abnormalities are detected, the pathologist may recommend follow-up actions, which could include scheduling another PAP smear at a shorter interval than usual or performing additional diagnostic tests such as colposcopy, endocervical curettage, or biopsy. These follow-up measures are essential for ensuring that any potential issues are addressed promptly and effectively.

Short Descr CYTOPATH C/V SELECT
Medium Descr CYTP SLIDES C/V MNL SCR&CPTR-RESCR CELL S&I
Long Descr Cytopathology, slides, cervical or vaginal; with manual screening and computer-assisted rescreening using cell selection and review under physician supervision
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 234 - Pathology
Date
Action
Notes
2017-12-31 Deleted Code deleted.
2013-01-01 Changed Medium Descriptor changed. Changed again per AMA 2013 corrections document.
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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