CPT® Code 81490

Autoimmune (rheumatoid arthritis), analysis of 12 biomarkers using immunoassays, utilizing serum, prognostic algorithm reported as a disease activity score

The CPT® Code 81490 refers to a specialized blood test designed to analyze autoimmune biomarkers specifically in patients diagnosed with rheumatoid arthritis (RA). This autoimmune disease is characterized by chronic inflammation of the joints, leading to pain, progressive destruction of joint tissue, and ultimately a loss of function. The test measures a total of 12 distinct biomarkers that are crucial for understanding the heterogeneity of an individual's disease. By identifying these biomarkers, healthcare providers can assess the severity of the condition and make informed decisions regarding therapeutic interventions. The biomarkers included in this analysis are Interleukin-6 (IL-6), Tumor necrosis factor receptor type 1 (TNFR1), Vascular cell adhesion molecule 1 (VCAM-1), Epidermal growth factor (EGF), Vascular endothelial growth factor A (VEGF-A), YKL-40, Matrix metalloproteinase 1 (MMP-1), Matrix metalloproteinase 3 (MMP-3), C-reactive protein (CRP), Serum amyloid A (SAA), Leptin, and Resistin. The test utilizes serum obtained from a blood sample, which is collected through a procedure known as venipuncture. The serum is then analyzed using multiplexed sandwiched immunoassays that employ biomarker-specific capture antibodies. The results of this analysis are reported as a multi-biomarker disease activity (MBDA) score, which ranges from 0 to 100, providing a prognostic algorithm that aids in the management of rheumatoid arthritis.