CPT® Code 81503

Oncology (ovarian), biochemical assays of five proteins (CA-125, apolipoprotein A1, beta-2 microglobulin, transferrin, and pre-albumin), utilizing serum, algorithm reported as a risk score

The CPT® Code 81503 pertains to a specific set of biochemical assays utilized in the field of oncology, particularly for evaluating the risk of ovarian cancer in women. This procedure involves the analysis of five distinct proteins: Cancer Antigen 125 (CA-125), apolipoprotein A1 (APO A1), beta-2 microglobulin, transferrin, and pre-albumin. These proteins are measured in serum obtained from a blood sample, which is collected through a separately reportable venipuncture. The results of these assays are then compiled into an algorithm that generates a risk score, providing valuable information regarding the likelihood of ovarian malignancy. The OVA1 assay, as indicated by this code, is specifically designed for women aged 18 years and older who present with an ovarian adnexal mass. This testing is particularly relevant when surgical intervention is being considered, and the patient has not yet been referred to an oncologist. The biochemical markers assessed in this test are critical for clinicians to make informed decisions regarding further diagnostic steps and potential treatment pathways. The methodology employed for testing includes quantitative electrochemiluminescent immunoassay for CA-125, quantitative nephelometry for APO A1, and quantitative immunoturbidimetry for the remaining proteins, ensuring accurate and reliable results that can guide clinical management.