CPT® Code 83068

The CPT® Code 83068 refers to a laboratory test specifically designed to screen for unstable hemoglobin. This blood test is crucial for identifying hemoglobin molecules that are unstable due to genetic mutations affecting the globin gene. Unstable hemoglobin is typically associated with a rare genetic disorder that is usually inherited in an autosomal dominant manner. This condition leads to changes in the solubility of hemoglobin, primarily due to the oxidation of amino acid residues within the globin chains. The screening is particularly indicated when a patient presents with unexplained hemolytic anemia, and it is essential to rule out other hemolytic disorders, such as sickle cell disease, fetal hemoglobin disorders, and methemoglobinemia, before proceeding with this test. It is important to note that test results for infants aged six months and younger may not be reliable, which can affect the interpretation of the findings. The procedure involves obtaining a blood sample through venipuncture, which is separately reportable, and the analysis is conducted on whole blood using visual methods to identify hemoglobin precipitates.