© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 91301 refers to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, specifically designed to combat coronavirus disease (COVID-19). This vaccine utilizes a novel approach by employing messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), which is a cutting-edge technology in vaccine development. The mRNA contained in the vaccine encodes the spike protein of the SARS-CoV-2 virus, which is critical for the virus's ability to infect human cells. Upon administration, the mRNA instructs the body's cells to produce copies of the spike protein, which the immune system identifies as foreign. This triggers an immune response, leading to the production of antibodies that can recognize and neutralize the virus if the individual is exposed in the future. The vaccine is preservative-free and is administered intramuscularly in a dosage of 100 mcg per 0.5 mL. It is important to note that this code specifically reports the supply of the vaccine itself, and the actual injection of the vaccine is reported separately using the appropriate administration code, which varies based on the dose given. The vaccine is part of a two-dose series, with a third dose now available for certain populations as recommended by the Centers for Disease Control and Prevention (CDC).
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