CPT® Code 91303

Deleted

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, DNA, spike protein, adenovirus type 26 (Ad26) vector, preservative free, 5x10¹⁰ viral particles/0.5 mL dosage, for intramuscular use

The CPT® Code 91303 refers to a specific vaccine designed to provide immunity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine is classified as a DNA vaccine that utilizes a viral vector approach, specifically employing a non-replicating human adenovirus type 26 (Ad26) as the delivery mechanism. The adenovirus vector is harmless and serves to transport the genetic material encoding the spike protein of the SARS-CoV-2 virus into the host's cells. Upon administration via intramuscular injection, the vaccine introduces the genetic instructions for the spike protein, prompting the body to produce copies of this protein. The immune system identifies these spike proteins as foreign entities, which triggers an immune response that includes the production of antibodies and the formation of immunological memory. This process is crucial for preparing the immune system to recognize and combat the actual virus if the individual is exposed in the future. It is important to note that this code specifically reports the supply of the Johnson and Johnson’s Janssen single-dose vaccine and its booster for individuals aged 18 years and older. The administration of the vaccine itself is documented separately using the appropriate administration code, which varies based on the dosage given.