© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 91309 refers to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, specifically designed to combat coronavirus disease (COVID-19). This vaccine utilizes a messenger RNA (mRNA) technology encapsulated in lipid nanoparticles (LNP), which is a method that allows the mRNA to be delivered effectively into human cells. The vaccine contains a dosage of 50 micrograms in a 0.5 mL volume and is formulated to be preservative-free, ensuring a safer administration for patients. The primary function of this vaccine is to stimulate the immune system by introducing a blueprint for the spike protein found on the surface of the SARS-CoV-2 virus. Upon administration via intramuscular injection, the body’s cells utilize this mRNA to produce the spike protein, which is then recognized as foreign by the immune system. This recognition prompts the immune system to generate antibodies, preparing the body to respond more effectively if exposed to the actual virus in the future. It is important to note that this code specifically reports the supply of the Moderna COVID-19 booster vaccine intended for adults aged 18 years and older. The vaccine is packaged in a manner that ensures safety and is provided in booster dose-only packaging, distinguishing it from primary dose vials. The administration of the vaccine itself is reported separately using the appropriate administration code, emphasizing the need for accurate coding in the billing process.
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