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Code deleted. See 91318, 91319, 91320, 91321, 91322.

Official Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, monovalent, preservative free, 5 mcg/0.5 mL dosage, adjuvant AS03 emulsion, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 91310 refers to a specific vaccine designed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine is characterized as a monovalent formulation, meaning it targets a single strain of the virus, and is preservative-free. Each dose contains 5 micrograms of the active ingredient in a 0.5 mL volume, and it is formulated with an adjuvant known as AS03 emulsion, which enhances the immune response. The vaccine is intended for intramuscular administration, specifically for adult patients aged 18 years and older. It is important to note that this code is applicable only for the booster dose, which is administered to individuals who have already completed a primary vaccination series with any authorized COVID-19 vaccine, including those developed by Pfizer, Moderna, or Johnson & Johnson. The mechanism of action involves the introduction of a viral spike protein DNA sequence into the body, which prompts the immune system to produce antibodies. These antibodies play a crucial role in recognizing and neutralizing the virus upon future exposure, thereby reducing the risk of severe illness. The administration of the vaccine itself is reported separately using the appropriate administration code, ensuring accurate billing and coding practices.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 91310 is indicated for the administration of the COVID-19 vaccine in specific circumstances. The following conditions outline the indications for this vaccine:

  • Booster Dose This vaccine is specifically indicated for use as a booster dose in adult patients aged 18 years and older who have completed a primary series of any approved COVID-19 vaccine, including those from Pfizer, Moderna, or Johnson & Johnson.
  • Protection Against SARS-CoV-2 The vaccine is intended to provide protection against the SARS-CoV-2 virus, which can lead to COVID-19, a potentially severe and life-threatening disease.

2. Procedure

The administration of the COVID-19 vaccine under CPT® Code 91310 involves several procedural steps that ensure the vaccine is delivered safely and effectively. The following steps outline the procedure:

  • Step 1: Patient Assessment Prior to administration, a thorough assessment of the patient is conducted to confirm eligibility for the booster dose. This includes verifying that the patient is at least 18 years old and has completed the primary vaccination series with an approved COVID-19 vaccine.
  • Step 2: Preparation of Vaccine The vaccine is prepared according to the manufacturer's guidelines. This includes ensuring that the vaccine is at the appropriate temperature and that the correct dosage of 5 mcg in a 0.5 mL volume is drawn into a sterile syringe.
  • Step 3: Administration The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm. Proper injection techniques are followed to minimize discomfort and ensure effective delivery of the vaccine.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is a standard practice to ensure patient safety following vaccination.

3. Post-Procedure

Following the administration of the COVID-19 vaccine under CPT® Code 91310, patients are advised on post-procedure care and expected outcomes. It is common for patients to experience mild side effects, such as soreness at the injection site, fatigue, or low-grade fever, which typically resolve within a few days. Patients should be informed about the importance of completing the vaccination series and the role of the booster in enhancing immunity against COVID-19. Additionally, they should be advised to report any unusual or severe reactions to their healthcare provider. Documentation of the vaccine administration, including the date, lot number, and site of injection, is essential for maintaining accurate medical records and ensuring compliance with vaccination tracking requirements.

Short Descr SARSCOV2 VAC 5MCG/0.5ML AS03
Medium Descr SARSCOV2 VACC 5MCG/0.5ML ADJT AS03 EMULSN IM USE
Long Descr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, monovalent, preservative free, 5 mcg/0.5 mL dosage, adjuvant AS03 emulsion, for intramuscular use
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
Date
Action
Notes
2025-01-01 Deleted First appearance of code deletion in codebook.
2023-11-01 Deleted Code deleted. See 91318, 91319, 91320, 91321, 91322.
2023-01-01 Added First appearance in codebook.
2022-08-31 Note Changes made to vaccine name, product & dosing information, & patient age (18 yrs and older).
2022-04-26 Added Published on AMA website. Effective upon receiving emergency Use Authorization or approval from the FDA.
2022-04-26 Note AMA guideline codes 0104A published to website. Effective upon receiving emergency Use Authorization or approval from the FDA
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