Need help choosing the right code?
Ask CasePilot about procedures, modifiers, bundling, and coding guidance.
Try CasePilot© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 91310 refers to a specific vaccine designed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine is characterized as a monovalent formulation, meaning it targets a single strain of the virus, and is preservative-free. Each dose contains 5 micrograms of the active ingredient in a 0.5 mL volume, and it is formulated with an adjuvant known as AS03 emulsion, which enhances the immune response. The vaccine is intended for intramuscular administration, specifically for adult patients aged 18 years and older. It is important to note that this code is applicable only for the booster dose, which is administered to individuals who have already completed a primary vaccination series with any authorized COVID-19 vaccine, including those developed by Pfizer, Moderna, or Johnson & Johnson. The mechanism of action involves the introduction of a viral spike protein DNA sequence into the body, which prompts the immune system to produce antibodies. These antibodies play a crucial role in recognizing and neutralizing the virus upon future exposure, thereby reducing the risk of severe illness. The administration of the vaccine itself is reported separately using the appropriate administration code, ensuring accurate billing and coding practices.
© Copyright 2026 Coding Ahead. All rights reserved.
The CPT® Code 91310 is indicated for the administration of the COVID-19 vaccine in specific circumstances. The following conditions outline the indications for this vaccine:
The administration of the COVID-19 vaccine under CPT® Code 91310 involves several procedural steps that ensure the vaccine is delivered safely and effectively. The following steps outline the procedure:
Following the administration of the COVID-19 vaccine under CPT® Code 91310, patients are advised on post-procedure care and expected outcomes. It is common for patients to experience mild side effects, such as soreness at the injection site, fatigue, or low-grade fever, which typically resolve within a few days. Patients should be informed about the importance of completing the vaccination series and the role of the booster in enhancing immunity against COVID-19. Additionally, they should be advised to report any unusual or severe reactions to their healthcare provider. Documentation of the vaccine administration, including the date, lot number, and site of injection, is essential for maintaining accurate medical records and ensuring compliance with vaccination tracking requirements.
| Short Descr | SARSCOV2 VAC 5MCG/0.5ML AS03 | Medium Descr | SARSCOV2 VACC 5MCG/0.5ML ADJT AS03 EMULSN IM USE | Long Descr | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, monovalent, preservative free, 5 mcg/0.5 mL dosage, adjuvant AS03 emulsion, for intramuscular use | APC Status Indicator | Non-Covered Service, not paid under OPPS | Berenson-Eggers TOS (BETOS) | none | MUE | Not applicable/unspecified. |
|
Date
|
Action
|
Notes
|
|---|---|---|
| 2025-01-01 | Deleted | First appearance of code deletion in codebook. |
| 2023-11-01 | Deleted | Code deleted. See 91318, 91319, 91320, 91321, 91322. |
| 2023-01-01 | Added | First appearance in codebook. |
| 2022-08-31 | Note | Changes made to vaccine name, product & dosing information, & patient age (18 yrs and older). |
| 2022-04-26 | Added | Published on AMA website. Effective upon receiving emergency Use Authorization or approval from the FDA. |
| 2022-04-26 | Note | AMA guideline codes 0104A published to website. Effective upon receiving emergency Use Authorization or approval from the FDA |
Get instant expert-level medical coding assistance.