© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 91310 refers to a specific vaccine designed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine is characterized as a monovalent formulation, meaning it targets a single strain of the virus, and is preservative-free. Each dose contains 5 micrograms of the active ingredient in a 0.5 mL volume, and it is formulated with an adjuvant known as AS03 emulsion, which enhances the immune response. The vaccine is intended for intramuscular administration, specifically for adult patients aged 18 years and older. It is important to note that this code is applicable only for the booster dose, which is administered to individuals who have already completed a primary vaccination series with any authorized COVID-19 vaccine, including those developed by Pfizer, Moderna, or Johnson & Johnson. The mechanism of action involves the introduction of a viral spike protein DNA sequence into the body, which prompts the immune system to produce antibodies. These antibodies play a crucial role in recognizing and neutralizing the virus upon future exposure, thereby reducing the risk of severe illness. The administration of the vaccine itself is reported separately using the appropriate administration code, ensuring accurate billing and coding practices.
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