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Official Description

Professional services for allergen immunotherapy in the office or institution of the prescribing physician or other qualified health care professional, including provision of allergenic extract; 2 stinging insect venoms

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Allergen immunotherapy, as described by CPT® Code 95131, is a specialized treatment aimed at managing allergies specifically related to stinging insects, which include bees, wasps, hornets, and yellow jackets. This therapeutic approach is initiated after conducting allergy testing to pinpoint the exact stinging insect allergen(s) responsible for the allergic reactions. The treatment regimen is structured into two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive progressively increasing doses of the allergenic extract(s) through injections, typically administered in the upper arm, with frequency ranging from one to three times per week. This phase generally spans a duration of 3 to 6 months. Following the build-up phase, patients transition to the maintenance phase, which involves monthly injections that can continue for an extended period of 3 to 5 years. The allergenic extract utilized in this therapy is prepared and provided by the prescribing physician or another qualified healthcare professional. For billing purposes, it is important to note that CPT® Code 95130 is used for the injection of a single stinging insect venom extract, while CPT® Code 95131 is specifically designated for the administration of two stinging insect venoms, with additional codes available for three, four, or five venoms as indicated.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Allergic Reactions to Stinging Insects Allergen immunotherapy is indicated for patients who exhibit allergic reactions to stinging insects such as bees, wasps, hornets, or yellow jackets. This treatment is particularly beneficial for individuals who have experienced severe allergic responses, including anaphylaxis, to these insect stings.

2. Procedure

Step 1: Allergy Testing Prior to initiating allergen immunotherapy, patients undergo allergy testing to identify specific stinging insect allergens. This testing is crucial for determining the appropriate allergenic extracts to be used in the immunotherapy regimen.

Step 2: Development of Immunotherapy Schedule Once the specific allergens are identified, a personalized immunotherapy schedule is developed. This schedule outlines the treatment phases, including the build-up and maintenance phases, tailored to the patient's needs.

Step 3: Build-Up Phase Administration During the build-up phase, patients receive injections of the allergenic extract(s) at increasing doses. These injections are typically administered in the upper arm and occur one, two, or three times per week. This phase is designed to gradually desensitize the patient to the allergens and usually lasts between 3 to 6 months.

Step 4: Maintenance Phase Administration After successfully completing the build-up phase, patients transition to the maintenance phase. In this phase, injections are administered monthly for a duration of 3 to 5 years. The goal of the maintenance phase is to sustain the desensitization achieved during the build-up phase and to provide long-term relief from allergic reactions.

Step 5: Provision of Allergenic Extract The allergenic extract used in the immunotherapy is prepared and provided by the physician or other qualified healthcare professional. This ensures that the extracts are tailored to the specific allergens identified during the testing phase.

3. Post-Procedure

Post-procedure care involves monitoring the patient for any immediate allergic reactions following the administration of the allergenic extract. Patients are typically advised to remain in the office for a short period after the injection to ensure their safety. Additionally, ongoing follow-up appointments are necessary to assess the effectiveness of the immunotherapy and to make any necessary adjustments to the treatment plan. Patients should also be educated on recognizing signs of an allergic reaction and the importance of adhering to the scheduled injections for optimal results.

Short Descr IMMNTX 2 STING INSECTS
Medium Descr PROF SVCS ALLG IMMNTX W/PRV XTRC 2 STING INSECT
Long Descr Professional services for allergen immunotherapy in the office or institution of the prescribing physician or other qualified health care professional, including provision of allergenic extract; 2 stinging insect venoms
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) M5D - Specialist - other
MUE 0
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
Date
Action
Notes
2013-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
2009-01-01 Changed Code description changed
Pre-1990 Added Code added.
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Description
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