© Copyright 2026 American Medical Association. All rights reserved.
Allergen immunotherapy, as described by CPT® Code 95131, is a specialized treatment aimed at managing allergies specifically related to stinging insects, which include bees, wasps, hornets, and yellow jackets. This therapeutic approach is initiated after conducting allergy testing to pinpoint the exact stinging insect allergen(s) responsible for the allergic reactions. The treatment regimen is structured into two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive progressively increasing doses of the allergenic extract(s) through injections, typically administered in the upper arm, with frequency ranging from one to three times per week. This phase generally spans a duration of 3 to 6 months. Following the build-up phase, patients transition to the maintenance phase, which involves monthly injections that can continue for an extended period of 3 to 5 years. The allergenic extract utilized in this therapy is prepared and provided by the prescribing physician or another qualified healthcare professional. For billing purposes, it is important to note that CPT® Code 95130 is used for the injection of a single stinging insect venom extract, while CPT® Code 95131 is specifically designated for the administration of two stinging insect venoms, with additional codes available for three, four, or five venoms as indicated.
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