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Code deleted, see 96999

Official Description

Multi-spectral digital skin lesion analysis of clinically atypical cutaneous pigmented lesions for detection of melanomas and high risk melanocytic atypia; one to five lesions

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 0400T refers to a specialized procedure known as multi-spectral digital skin lesion analysis, which is utilized for the evaluation of clinically atypical cutaneous pigmented lesions. This non-invasive technique employs a handheld scanner that emits a range of light wavelengths, from visible light to near-infrared. The emitted light penetrates the skin lesion to a depth of up to 2.5 millimeters, allowing for an in-depth examination of the cellular structure beneath the skin's surface. The data collected during this scanning process is subsequently analyzed using advanced computer software, which organizes the information into a specific algorithm. Each lesion is then assigned an algorithmic score that ranges from less than 0, indicating a negative or low suspicion of morphological disorganization, to 0 or more, which suggests a positive or high degree of morphological disorganization. This scoring system is crucial as it aids healthcare providers in determining the nature of the skin lesions. Lesions that receive a positive score are recommended for further histological examination, such as a biopsy, to confirm the presence of malignancy or atypical cells. Conversely, lesions that are scored negatively can be monitored over time for any changes that may indicate a progression towards malignancy. The primary purpose of this multi-spectral digital skin lesion analysis is to assist physicians and qualified healthcare providers in classifying ambiguous skin lesions, identifying early-stage melanomas, recognizing high-risk melanocytic atypia, and detecting other suspicious pigmented lesions. It is important to note that CPT® Code 0400T encompasses the analysis of one to five lesions, while the analysis of six or more lesions is covered under CPT® Code 0401T.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The multi-spectral digital skin lesion analysis is indicated for the evaluation of clinically atypical cutaneous pigmented lesions. This procedure is particularly useful for the following conditions:

  • Clinically Atypical Lesions - Lesions that exhibit characteristics that are not typical and may require further investigation to determine their nature.
  • Early Melanomas - The procedure assists in the early detection of melanoma, a serious form of skin cancer that can develop from atypical moles.
  • High-Risk Melanocytic Atypia - Identification of lesions that show signs of atypical melanocytic cells, which may indicate a higher risk for developing melanoma.
  • Suspicious Pigmented Lesions - Lesions that appear suspicious based on visual examination and may warrant further diagnostic evaluation.

2. Procedure

The multi-spectral digital skin lesion analysis involves several key procedural steps to ensure accurate assessment of the skin lesions. The process begins with the patient being positioned comfortably, and the area of interest is prepared for examination. The healthcare provider then utilizes a handheld scanner that emits multi-spectral light, which includes wavelengths from visible light to near-infrared. This scanner is carefully placed over the skin lesion, allowing the light to penetrate the lesion to a depth of up to 2.5 millimeters. As the light interacts with the skin cells, it captures detailed information regarding the cell morphology beneath the surface. This data is then transmitted to a computer software program designed to analyze the information collected during the scan. The software processes the data and organizes it into an algorithm that evaluates the characteristics of the lesion. Each lesion is assigned an algorithmic score, which ranges from less than 0 to 0 or more, indicating the level of suspicion regarding morphological disorganization. If the score indicates a positive result, suggesting a high degree of morphological disorganization, the healthcare provider will recommend further histological examination, such as a biopsy, to confirm the diagnosis. In cases where the score is negative, indicating low suspicion, the lesions can be monitored over time for any changes that may occur. This comprehensive approach allows for effective classification and management of skin lesions, enhancing the ability to detect potential malignancies early.

3. Post-Procedure

After the multi-spectral digital skin lesion analysis, the healthcare provider will discuss the results with the patient, explaining the algorithmic score assigned to each lesion. If any lesions are identified as positive and warrant further investigation, the provider will outline the next steps, which may include scheduling a biopsy or additional diagnostic tests. For lesions that are scored negatively, the provider may recommend a follow-up plan to monitor the lesions over time, ensuring that any changes are promptly addressed. Patients may be advised on signs to watch for that could indicate changes in the lesions, such as alterations in size, shape, color, or texture. Overall, the post-procedure care focuses on ensuring that patients are informed and that any necessary follow-up actions are clearly communicated to maintain optimal skin health.

Short Descr MLTISPECTRL DIGITAL LES ALYS
Medium Descr MULTI-SPECTRAL DIGITAL SKIN LES ANALYSIS 1-5 LES
Long Descr Multi-spectral digital skin lesion analysis of clinically atypical cutaneous pigmented lesions for detection of melanomas and high risk melanocytic atypia; one to five lesions
Status Code Carriers Price the Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) M5A - Specialist - pathology (HCPCS moved to T1G in 2003)
MUE Not applicable/unspecified.
Date
Action
Notes
2020-12-31 Deleted Code deleted, see 96999
2016-01-01 Added Added
Code
Description
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