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Code deleted, see 96999

Official Description

Multi-spectral digital skin lesion analysis of clinically atypical cutaneous pigmented lesions for detection of melanomas and high risk melanocytic atypia; six or more lesions

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 0401T refers to a multi-spectral digital skin lesion analysis specifically designed for the evaluation of clinically atypical cutaneous pigmented lesions. This non-invasive procedure utilizes a handheld scanner that emits a range of light wavelengths, from visible light to near-infrared. The emitted light penetrates the skin lesion to a depth of up to 2.5 millimeters, allowing for an in-depth examination of the cellular structure beneath the skin's surface. The data collected during this scanning process is processed by specialized computer software, which analyzes the information and organizes it into an algorithmic format. Each lesion is then assigned an algorithmic score that ranges from less than 0, indicating a negative or low suspicion of morphological disorganization, to 0 or more, which signifies a positive or high degree of morphological disorganization. This scoring system aids healthcare providers in determining the nature of the lesions. Lesions that receive a positive score are recommended for further histological examination, such as a biopsy, while those with a negative score can be monitored over time for any changes. The application of multi-spectral digital skin lesion analysis is particularly beneficial for healthcare professionals in classifying ambiguous skin lesions, detecting early melanomas, identifying high-risk melanocytic atypia, and recognizing other suspicious pigmented lesions. It is important to note that CPT® Code 0401T is specifically for the analysis of six or more lesions, distinguishing it from CPT® Code 0400T, which covers the analysis of one to five lesions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The multi-spectral digital skin lesion analysis using CPT® Code 0401T is indicated for the evaluation of clinically atypical cutaneous pigmented lesions. This procedure is particularly useful in the following scenarios:

  • Detection of Melanomas This procedure assists in the early identification of melanomas, which are aggressive forms of skin cancer that can develop from atypical pigmented lesions.
  • High-Risk Melanocytic Atypia The analysis helps in identifying lesions that exhibit high-risk characteristics for melanocytic atypia, which may indicate a potential for malignancy.
  • Monitoring Suspicious Pigmented Lesions The procedure is beneficial for monitoring changes in clinically ambiguous skin lesions over time, allowing for timely intervention if necessary.

2. Procedure

The multi-spectral digital skin lesion analysis procedure involves several key steps to ensure accurate evaluation of the lesions. The following outlines the procedural steps:

  • Step 1: Preparation The patient is positioned comfortably, and the skin lesions to be analyzed are identified. The area may be cleaned to ensure optimal scanning conditions.
  • Step 2: Scanning A handheld scanner is utilized to emit wavelengths of light that penetrate the skin lesions. This scanner is designed to cover multiple lesions, specifically six or more, as indicated by CPT® Code 0401T.
  • Step 3: Data Collection As the scanner emits light, it collects data regarding the cellular morphology of the lesions. This data is crucial for the subsequent analysis.
  • Step 4: Algorithmic Analysis The collected data is processed by specialized computer software, which analyzes the information and generates an algorithmic score for each lesion based on the degree of morphological disorganization.
  • Step 5: Interpretation of Results The algorithmic scores are reviewed, with scores less than 0 indicating low suspicion and scores of 0 or more indicating a high degree of suspicion for malignancy. This information guides further clinical decisions.

3. Post-Procedure

After the multi-spectral digital skin lesion analysis is completed, the healthcare provider will discuss the results with the patient. For lesions that receive a positive algorithmic score, further histological examination, such as a biopsy, is recommended to confirm the diagnosis and determine the appropriate course of action. In contrast, lesions that are scored negatively can be monitored over time for any changes, with follow-up appointments scheduled as necessary. The provider may also advise on any additional skin care or monitoring strategies to ensure the patient's ongoing skin health.

Short Descr MLTISPECTRL DIGITAL LES ALYS
Medium Descr MULTI-SPECTRAL DIGITAL SKIN LES ANALYSIS 6+ LES
Long Descr Multi-spectral digital skin lesion analysis of clinically atypical cutaneous pigmented lesions for detection of melanomas and high risk melanocytic atypia; six or more lesions
Status Code Carriers Price the Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) M5A - Specialist - pathology (HCPCS moved to T1G in 2003)
MUE Not applicable/unspecified.
Date
Action
Notes
2020-12-31 Deleted Code deleted, see 96999
2016-01-01 Added Added
Code
Description
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