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A tissue cultured allogeneic dermal substitute is a specialized medical product used to treat wounds or skin defects on various parts of the body, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This substitute is derived from human fibroblast cells, which are essential components of the skin that help in wound healing and tissue regeneration. The fibroblasts are cultivated from newborn foreskin tissue and are then seeded onto a bioabsorbable mesh scaffold. As these fibroblasts proliferate, they fill the mesh scaffold and secrete important substances such as human dermal collagen, matrix proteins, growth factors, and cytokines. These substances play a crucial role in regulating the immune response and promoting healing. The end product is a metabolically active, living dermal substitute that can effectively cover and support the healing of skin defects. During the procedure, the dermal substitute is carefully removed from its transport container and applied to a prepared wound bed, where it is secured in place using sutures or staples. Following this, a layered dressing is applied to protect the substitute and facilitate healing, which includes a nonadherent layer, a bulky layer of gauze, a compression layer, and an anti-shear layer. This procedure is coded as 15365 for the first 100 square centimeters or less in adults or for 1% of total body surface area in infants and children, while 15366 is used for each additional 100 square centimeters or 1% of total body surface area in infants and children or part thereof.
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