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A tissue cultured allogeneic dermal substitute is a specialized medical product used to treat wounds or skin defects on various parts of the body, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This substitute is derived from human fibroblast cells, which are essential components of the skin that help in wound healing and tissue regeneration. The fibroblasts are cultivated from newborn foreskin tissue and are then seeded onto a bioabsorbable mesh scaffold. As these fibroblasts proliferate, they fill the mesh scaffold and produce important substances such as human dermal collagen, matrix proteins, growth factors, and cytokines. These components play a crucial role in regulating the immune response and promoting healing. The resulting dermal substitute is metabolically active and contains living cells, making it a dynamic option for wound coverage. During the procedure, the dermal substitute is carefully removed from its transport container and applied to a prepared wound bed, where it is secured using sutures or staples. Following this, a layered dressing is applied to protect the substitute and facilitate healing, which includes a nonadherent layer, a bulky layer of gauze, a compression layer, and an anti-shear layer. For billing purposes, CPT® Code 15365 is used for the first 100 square centimeters or less in adults or for 1% of total body surface area (TBSA) in infants and children, while CPT® Code 15366 is designated for each additional 100 square centimeters in adults or each additional 1% of TBSA in infants and children, or part thereof.
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