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Code deleted, see 81200-81479

Official Description

Molecular diagnostics; mutation identification by allele specific transcription, single segment, each segment

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Molecular diagnostics play a crucial role in the identification of genetic mutations that may indicate the presence of certain diseases, even in the absence of overt symptoms. This process involves analyzing specific segments of DNA to detect variations that could be linked to various health conditions. An allele refers to one of the different forms of a gene that can exist at a specific location on a chromosome. The test described by CPT® Code 83905 focuses on the identification of a single segment allele through a method known as allele-specific transcription. This technique allows for precise detection of mutations, which can be vital for diagnosis, treatment planning, and understanding the genetic predisposition to certain diseases. By utilizing this molecular diagnostic approach, healthcare providers can gain insights into a patient's genetic makeup, facilitating more personalized and effective medical care.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 83905 is indicated for the identification of specific genetic mutations that may be relevant to various diseases. This testing is particularly useful in the following scenarios:

  • Genetic Testing for Hereditary Conditions This test is performed to identify mutations that may be inherited and could lead to hereditary diseases.
  • Oncology It is utilized in cancer diagnostics to detect mutations that may influence treatment decisions and prognostic evaluations.
  • Pharmacogenomics The procedure can assist in determining how genetic variations affect an individual's response to certain medications.

2. Procedure

The procedure for CPT® Code 83905 involves several key steps to ensure accurate mutation identification through allele-specific transcription. Each step is critical for the successful execution of the test:

  • Sample Collection A biological sample, typically blood or tissue, is collected from the patient. This sample serves as the source of DNA for analysis.
  • DNA Extraction The DNA is extracted from the collected sample using standardized laboratory techniques to ensure purity and integrity for testing.
  • Allele-Specific Transcription The extracted DNA undergoes allele-specific transcription, where specific segments of the DNA are transcribed to identify the presence of particular alleles associated with mutations.
  • Data Analysis The results of the transcription are analyzed to determine the presence or absence of the targeted mutations, providing critical information for diagnosis and treatment.

3. Post-Procedure

After the completion of the procedure associated with CPT® Code 83905, the patient may not require any specific post-procedure care related to the test itself, as it is a laboratory-based analysis. However, it is essential for healthcare providers to discuss the results with the patient once they are available. This discussion may include the implications of the findings, potential next steps in management or treatment, and any necessary follow-up testing or evaluations based on the identified mutations. Additionally, patients may be advised to monitor for any symptoms related to the conditions being tested, as well as to maintain regular communication with their healthcare provider regarding their health status.

Short Descr MOLECULE MUTATION IDENTIFY
Medium Descr MOLECULE MUTATION IDENTIFY
Long Descr Molecular diagnostics; mutation identification by allele specific transcription, single segment, each segment
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Discontinued Code
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2013-01-01 Deleted Code deleted, see 81200-81479
2013-01-01 Changed Short and Medium Descriptors changed.
1999-01-01 Added Code added.
Code
Description
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