Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot
Code deleted, see 81200-81479

Official Description

Molecular diagnostics; mutation identification by allele specific translation, single segment, each segment

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Molecular diagnostics play a crucial role in the identification of genetic mutations that may indicate the presence of certain diseases, even in the absence of overt symptoms. This process involves analyzing specific segments of DNA to detect variations that could be associated with various health conditions. An allele refers to one of the different forms of a gene that can exist at a particular location on a chromosome. The test described by CPT® Code 83906 focuses on the identification of a single segment allele through a method known as allele-specific translation. This technique allows for precise detection of mutations, which can be vital for diagnosis, treatment planning, and understanding the genetic predisposition to certain diseases. By utilizing this molecular diagnostic approach, healthcare providers can gain insights into a patient's genetic makeup, facilitating more personalized and effective medical care.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 83906 is indicated for the identification of specific genetic mutations that may be relevant to various diseases. This testing is particularly useful in the following scenarios:

  • Genetic Testing for Hereditary Conditions This test is performed to identify mutations that may be inherited and could lead to hereditary diseases.
  • Oncology It is utilized in cancer diagnostics to detect mutations that may influence treatment decisions and prognostic evaluations.
  • Pharmacogenomics The procedure can assist in determining how genetic variations affect an individual's response to certain medications.

2. Procedure

The procedure for CPT® Code 83906 involves several key steps to ensure accurate mutation identification through allele-specific translation. Each step is critical for the successful execution of the test:

  • Sample Collection A biological sample, typically blood or tissue, is collected from the patient. This sample serves as the source of DNA for analysis.
  • DNA Extraction The DNA is extracted from the collected sample using standardized laboratory techniques to ensure purity and integrity for testing.
  • Allele-Specific Translation The extracted DNA is subjected to allele-specific translation, where specific primers are used to amplify the target segment of DNA that contains the mutation of interest. This step is crucial for isolating the segment that will be analyzed.
  • Mutation Identification The amplified DNA is then analyzed to identify the presence of specific mutations. This may involve various molecular techniques, such as sequencing or hybridization, to confirm the presence of the allele.
  • Result Interpretation Finally, the results are interpreted by qualified laboratory personnel, and a report is generated detailing the findings, which can then be used by healthcare providers for further clinical decision-making.

3. Post-Procedure

After the completion of the procedure associated with CPT® Code 83906, the patient may not require any specific post-procedure care, as the test is non-invasive and typically does not involve any physical intervention. However, it is essential for healthcare providers to discuss the results with the patient once they are available. This discussion may include the implications of the identified mutations, potential health risks, and any necessary follow-up actions or treatments based on the findings. Additionally, patients may be advised to maintain regular follow-up appointments to monitor any health changes related to the identified genetic mutations.

Short Descr MOLECULE MUTATION IDENTIFY
Medium Descr MOLECULE MUTATION IDENTIFY
Long Descr Molecular diagnostics; mutation identification by allele specific translation, single segment, each segment
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Discontinued Code
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2013-01-01 Deleted Code deleted, see 81200-81479
2013-01-01 Changed Short and Medium Descriptors changed.
1999-01-01 Added Code added.
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"