CPT® Code 90291

The CPT® Code 90291 refers to human cytomegalovirus immune globulin (CMV-IgIV), which is specifically formulated for intravenous use. This immunizing agent is a concentrated solution containing antibodies that provide effective, short-term passive immunity to individuals exposed to cytomegalovirus (CMV). Unlike active immunization, where the recipient's immune system is stimulated to produce its own antibodies, CMV-IgIV offers passive protection by supplying pre-formed antibodies directly into the bloodstream. These antibodies are derived from the pooled blood of multiple donors who have previously developed immunity to CMV, ensuring a robust source of protective agents. The administration of this immune globulin is crucial for individuals at high risk of CMV infection, as it helps to mitigate the potential effects of the virus without requiring the recipient's immune system to engage in antibody production. This code is specifically used to report the use of CMV-IgIV and does not encompass any additional services or procedures associated with its administration.