CPT® Code 90396

The varicella-zoster immune globulin (VZIG) is a specialized immunizing agent designed to provide immediate, short-term passive immunity against the varicella-zoster virus, which is responsible for causing chickenpox. This immune globulin is formulated as a concentrated solution containing antibodies that are derived from the pooled blood of multiple donors who have previously developed immunity to the virus. Unlike active immunization, where the recipient's immune system is stimulated to produce its own antibodies, VZIG offers passive protection by supplying pre-formed antibodies directly into the bloodstream. This means that the recipient does not need to rely on their immune system to generate a response, making it particularly useful in situations where immediate protection is necessary, such as in individuals who are at high risk of severe disease following exposure to the varicella-zoster virus. The administration of this immune globulin is performed via intramuscular injection, and the CPT® Code 90396 specifically identifies this product for billing and coding purposes, ensuring accurate reporting of the use of human varicella-zoster immune globulin in clinical settings.