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Official Description

Diphtheria antitoxin, equine, any route

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Equine diphtheria antitoxin is a specialized immunizing agent that provides passive immunity to individuals exposed to diphtheria. This antitoxin is derived from the blood serum of horses that have been immunized against the diphtheria toxin, allowing them to produce specific antibodies. When administered to a recipient, these antibodies circulate throughout the body and work to neutralize the harmful toxins produced by the diphtheria bacteria. The administration of this antitoxin can occur via any route, making it versatile in its application. It is important to note that this CPT® code specifically reports the use of the diphtheria antitoxin product itself, rather than the procedure or method of administration. This distinction is crucial for accurate medical coding and billing, ensuring that healthcare providers are appropriately reimbursed for the use of this vital immunizing agent.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The diphtheria antitoxin is indicated for use in patients who have been diagnosed with diphtheria or are suspected of having been exposed to the diphtheria bacteria. The following conditions warrant the administration of this antitoxin:

  • Diphtheria Diagnosis Patients presenting with clinical signs and symptoms consistent with diphtheria, such as a sore throat, fever, and the presence of a pseudomembrane in the throat.
  • Exposure to Diphtheria Individuals who have been in close contact with someone diagnosed with diphtheria, particularly in outbreak situations.

2. Procedure

The administration of diphtheria antitoxin involves several key procedural steps to ensure safety and efficacy:

  • Step 1: Patient Assessment Prior to administration, a thorough assessment of the patient is conducted to confirm the diagnosis of diphtheria or potential exposure. This includes reviewing the patient's medical history, current symptoms, and any previous vaccinations against diphtheria.
  • Step 2: Preparation of Antitoxin The diphtheria antitoxin is prepared according to the manufacturer's guidelines. This may involve checking the expiration date, ensuring proper storage conditions, and preparing the appropriate dosage based on the patient's weight and clinical condition.
  • Step 3: Administration The antitoxin is administered via the chosen route, which may include intramuscular, intravenous, or subcutaneous injection. The healthcare provider must follow aseptic techniques to minimize the risk of infection during the procedure.
  • Step 4: Monitoring After administration, the patient is monitored for any immediate adverse reactions or side effects, such as allergic reactions or anaphylaxis. Vital signs are typically checked, and the patient is observed for a specified period to ensure their safety.

3. Post-Procedure

Following the administration of diphtheria antitoxin, patients may require additional monitoring to assess for any delayed reactions. It is essential to provide the patient with information regarding potential side effects and the importance of follow-up care. Patients should be advised to seek medical attention if they experience any unusual symptoms or reactions. Additionally, healthcare providers may recommend vaccination against diphtheria as part of the patient's long-term preventive care strategy, depending on their vaccination history and current health status.

Short Descr DIPHTHERIA ANTITOXIN
Medium Descr DIPHTHERIA ANTITOXIN EQUINE ANY ROUTE
Long Descr Diphtheria antitoxin, equine, any route
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) P6D - Minor procedures - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
1999-01-01 Added First appearance in code book in 1999.
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