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Official Description

Rho(D) immune globulin (RhIg), human, full-dose, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The Rho(D) immune globulin (RhIg) is a specialized immunizing agent that is administered to provide passive immunity to individuals at risk of Rh incompatibility. This immunoglobulin is a concentrated solution of antibodies derived from the pooled blood of multiple donors, ensuring a broad spectrum of protective antibodies. The primary function of RhIg is to prevent the immune system of an Rh-negative individual from producing antibodies against Rh-positive red blood cells, which can occur during pregnancy or blood transfusions. This passive immunity is crucial in scenarios where the recipient's immune system is not activated to produce its own antibodies, thus offering immediate protection against potential hemolytic reactions. The full-dose formulation, represented by CPT® Code 90384, is specifically intended for intramuscular administration, allowing for effective absorption and distribution of the antibodies throughout the body. It is important to note that this code exclusively reports the product used, without implications regarding the clinical scenarios or guidelines for its administration.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Rho(D) immune globulin (RhIg) is indicated for use in specific clinical situations where there is a risk of Rh incompatibility. The following conditions warrant the administration of RhIg:

  • Pregnancy Administration is indicated for Rh-negative mothers who are carrying an Rh-positive fetus to prevent the development of Rh antibodies that could affect current or future pregnancies.
  • Blood Transfusions It is used in Rh-negative individuals receiving Rh-positive blood transfusions to prevent sensitization to Rh-positive red blood cells.
  • Postpartum Care RhIg is indicated for Rh-negative women after delivery of an Rh-positive infant to prevent Rh immunization.

2. Procedure

The administration of Rho(D) immune globulin involves several key procedural steps to ensure safety and efficacy:

  • Step 1: Patient Assessment Prior to administration, the healthcare provider must assess the patient's Rh status and determine the need for RhIg based on clinical indications such as pregnancy or recent blood transfusion.
  • Step 2: Preparation of the Product The full-dose Rho(D) immune globulin is prepared for intramuscular injection. This involves checking the product for integrity, ensuring it is within the expiration date, and following aseptic techniques to maintain sterility.
  • Step 3: Administration The RhIg is administered intramuscularly, typically in the deltoid muscle or the anterolateral thigh, using a suitable needle gauge. The injection site should be cleaned with an antiseptic prior to administration.
  • Step 4: Post-Administration Monitoring After the injection, the patient should be monitored for any immediate adverse reactions, and appropriate documentation should be completed to record the administration of the immune globulin.

3. Post-Procedure

Following the administration of Rho(D) immune globulin, patients are generally advised to remain under observation for a short period to monitor for any potential allergic reactions or side effects. It is important to provide patients with information regarding possible mild side effects, such as soreness at the injection site or low-grade fever. Additionally, patients should be informed about the importance of follow-up care, especially in the context of pregnancy or subsequent transfusions, to ensure ongoing monitoring of Rh status and the need for additional doses of RhIg if necessary.

Short Descr RH IG FULL-DOSE IM
Medium Descr RHO(D) IMMUNE GLOBULIN HUMAN FULL-DOSE IM
Long Descr Rho(D) immune globulin (RhIg), human, full-dose, for intramuscular use
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) P6D - Minor procedures - other (non-Medicare fee schedule)
MUE 0
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
AH Clinical psychologist
AJ Clinical social worker
Date
Action
Notes
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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