© Copyright 2026 American Medical Association. All rights reserved.
The Rho(D) immune globulin (RhIg) is a specialized immunizing agent that is administered to provide passive immunity to individuals at risk of Rh incompatibility. This immunoglobulin is a concentrated solution of antibodies derived from the pooled blood of multiple donors, ensuring a broad spectrum of protective antibodies. The primary function of RhIg is to prevent the immune system of an Rh-negative individual from producing antibodies against Rh-positive red blood cells, which can occur during pregnancy or blood transfusions. This passive immunity is crucial in scenarios where the recipient's immune system is not activated to produce its own antibodies, thus offering immediate protection against potential hemolytic reactions. The full-dose formulation, represented by CPT® Code 90384, is specifically intended for intramuscular administration, allowing for effective absorption and distribution of the antibodies throughout the body. It is important to note that this code exclusively reports the product used, without implications regarding the clinical scenarios or guidelines for its administration.
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